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Cardiovascular & Metabolic Health


Atlantia Food Clinical Trials has experience in conducting trials and food clinical research in the assessment of food claim validation in the related areas of cardiovascular health, metabolic health and obesity. Our researcher team will work with the client company to design a study most suitable for their products, analysing EFSA Guidelines1,2 and opinions, peer-reviewed publications, agreeing the most suitable end-points and statistically powering studies to ensure that studies will meet requirements.  Some of the various clinical factors that we can evaluate include;

Cardiovascular health

  • Lipid and lipoprotein profiles - total cholesterol, LDL cholesterol, HDL cholesterol, Apolipoprotein A1 and B, triglycerides, Omega 3 fatty acids EPA/DHA, Conjugated Linoleic acid
  • Inflammatory/cardiovascular markers - hsCRP, inflammatory cytokines, bradykinin, cortisol, ACE inhibition
  • Blood pressure - systolic/diastolic blood pressure, ambulatory blood pressure (e.g. 48hr)
  • Blood flow - endothelial function e.g. flow mediated dilation (FMD)

Metabolic Health/Obesity

  • Body composition/body weight  - lean muscle, % body fat, % body water etc. using DEXA or Tanita anthropometic measurements - waist body composition analyser (bioimpedance)
  • Satiety related hormones - leptin, ghrelin, cholecystokinin plasma, GLP1, growth hormones
  • Metabolic markers, including post prandial blood glucose (e.g. 2hours), insulin, adiponectin, glucagon
  • Behavioural assessments - appetite profile using visual analogue scales (VAS), reduced sense of hunger
  • Energy and nutrient intake
  • Weight management 
  • Physical performance studies- exercise/daily activity log & questionnaires, strength/endurance testing
  • Quality of Life (QoL) questionnaires
  • Validation of nutrition claims
  1. Guidance on the scientific requirements for health claims related to appetite ratings, weight management and blood glucose concentration. EFSA J., 2012, 10(3): 2604
  2. Guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health. EFSA J., 2011, 9 (12): 2474

 

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